2024 and 2025 Mid-Career Leadership Development Program updates
Congratulations to associate professors Quanhu "Tiger" Sheng and Andrew Spieker on being selected for Vanderbilt University School of Medicine's Mid-Career Leadership Development Program (MCLDP). This year-long career development program is designed to cultivate and prepare Vanderbilt faculty for future success as medical center leaders.
As deputy technical director of Vanderbilt Technologies for Advanced Genomics Analysis and Research Design (VANGARD), a role he has filled since 2015, Dr. Sheng provides crucial supervision and training for personnel involved with large-scale initiatives such as the migration of VUMC’s BioVU repository (the world’s largest DNA biobank based at a single academic institution) to the cloud. His responsibilities include helping analytical staff and application developers to best assist users across a wide spectrum (from quantitatively untrained to highly experienced) and anticipate their needs, and representing the chair in multi-institutional working group meetings. He has been indispensable in VANGARD’s construction and maintenance of the genomics data pipeline that has fed into dozens of projects led by Vanderbilt PIs, and his expertise will become even more crucial as VUMC scales up its service to the Alliance for Genomic Discovery.
A well-regarded investigator who has made a name for himself in both statistical methods and collaborative biomedical research, Dr. Spieker is exceptionally passionate about providing top-notch teaching and mentoring. The graduate student body has named him Outstanding Faculty Mentor twice and bestowed on him its Golden Apple Award for Excellence in Teaching in 2021; he was inducted into the Academy for Excellence in Education earlier this year. He has also been vital to the success of Vanderbilt Biostatistics' graduate program as chair of the Comprehensive Exam Committee and member of its Executive Committee, and conducted dozens of evaluations during the past year as co-chair of the Faculty Search Committee and member of the planning and selection team for the Summer Internships for Underrepresented Undergraduates program. In the wider scientific community, he has served on the Regional Advisory Board of ENAR (Eastern North American Region of the International Biometric Society) and as Biometrics Section program chair for the Joint Statistical Meetings (JSM)—the two highest-profile conferences in the biostatistics field. He was also recently elected book review editor of Biometrics, long regarded as one of the most prestigious peer-reviewed journals in the field.
Past MCLDP participants include Fei Ye, Qi Liu, and Ben French. On December 13, the 2024 cohort presented the novel strategic plans they had developed during their year of training to academic medical center stakeholders; these snapshots of 2024 participant Mario Davidson were taken by department chair Yu Shyr.
Bryan Helm promoted to principal statistical genetic analyst
We are pleased to announce the promotion of Bryan Helm to principal statistical genetic analyst, effective November 1. Helm earned a BA cum laude in biology at DePauw University, followed by his MS and PhD in ecology and evolutionary biology at the University of Arizona. He was then a postdoc at North Dakota State University (funded by the USDA and NSF) and Indiana University School of Medicine (supported by a T32 fellowship for work in pediatric clinical and developmental pharmacology).
Transitioning into bioinformatics and joining the Department of Biostatistics in 2021, Helm supports research projects with genomic, transcriptomic, and next-generation sequencing analysis, including single-cell and spatial methods. His bibliography includes first-authored papers in Journal of Experimental Biology, Journal of Insect Physiology, Biology Open, and Proceedings of the National Academy of Sciences (PNAS). His recent work includes identifying functionally distinct thymic DC subsets and elucidating requirements for crosstalk with thymocyte subsets that support their homeostasis and activation, with a preprint posted at bioRxiv; members of that team include biostatistics and bioinformatics professor Qi Liu, Vanderbilt University Medical Center colleagues Cody Heiser and Ken Lau, and investigators at the University of Texas at Austin. Outside of work, his activities include serving as an umpire for the West Nashville Sports League.
Study identifies that higher West African ancestry may contribute to worse breast cancer outcomes
Co-authors include principal biostatistician Run Fan and professor Fei Ye.
Hui Nian promoted to research assistant professor
We are pleased to announce the promotion of Hui Nian to research assistant professor of biostatistics and orthopaedic surgery, effective December 1. After earning her BS in biology and MS in cell biology from Beijing Normal University, followed by her MS in statistics and PhD in biochemistry at Oregon State University, Dr. Nian joined Vanderbilt University Medical Center in 2010 as a biostatistician. She was appointed to the faculty as Assistant in Biostatistics in 2018, with a secondary appointment in Orthopaedic Surgery added in 2022. Dr. Nian has published more than one hundred peer-reviewed papers, including first-authored articles in the Journal of Applied Statistics ("Performance evaluation of propensity score methods for estimating average treatment effects with multi-level treatments," 2018) and Nicotine & Tobacco Research ("Demographic characteristics, perinatal smoking patterns, and risk for neonatal health complications among pregnant smokers in the United States who begin using electronic cigarettes during pregnancy: A descriptive study using population-based surveillance data," 2024). In demand as a content expert and experienced collaborative statistician among multiple departments at Vanderbilt University Medical Center, Dr. Nian chaired this year's Patrick G. Arbogast Collaborative Publication Award Committee.
Statistical Computing Series: What I look for in a code review
The Statistical Computing Series hosted by Vanderbilt University Medical Center's Department of Biostatistics features presentations on the implementation of statistical models and methods, statistical computation, and graphics. These informal meetings allow experienced statisticians and developers to share their expertise on computing topics with practitioners across Vanderbilt. On Thursday, December 12, 2024, at 2:30 pm Central Time on Teams, principal application developer Cole Beck will present "What I look for in a code review." Here is his description:
Have you ever had your code reviewed, or had to review someone else's? I occasionally have the chance to evaluate someone else's R code - it's always a valuable learning experience for myself and the author. In this talk I'll provide common potential issues I look for in a review, as well as several example solutions.
For access to this webinar, contact series organizer Ryan Moore.
Beck is a 2023 IT Innovation Award winner, and the student body bestowed on him the Golden Apple Award for Excellence in Teaching in 2022. His service to the department also includes contributing to the Vanderbilt Biostatistics Summer Internship for Underrepresented Undergraduate program as a planning and selection committee member and instructor.
Caroline Birdrow promoted to senior biostatistician
We are pleased to announce the promotion of Caroline Birdrow to senior biostatistician, effective November 1. Originally from New Orleans, Birdrow earned her bachelor's degree in mathematics from Washington and Lee University, with a minor in poverty and human capability studies, and a term abroad in China on management accounting. For her MS in biostatistics from Vanderbilt, she completed her thesis, "Cumulative Probability Models for Semiparametric G-Computation," under the supervision of associate professor Andrew Spieker. At Vanderbilt University Medical Center since 2021, Birdrow has collaborated primarily with Vanderbilt's Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center; her duties as a biostatistician have included completing data safety monitoring board reports for randomized controlled trials, managing and analyzing observational study data, leading project meetings, and conducting a variety of ancillary analyses in relation to larger projects. She is a 2023 and 2024 winner of travel awards from Women in Statistics and Data Science, a graduate of the ISTAART (International Society to Advance Alzheimers Research and Treatment) Design and Data Analytics PIA (Professional Interest Area) Workshop on applying novel models for longitudinal continuous outcomes (including cognitive function), and a co-author of peer-reviewed papers in JAMA Network Open and Critical Care Medicine. As an ASA (American Statistical Association) GivesBack leader, she has judged the ASA's Fall Data Challenge and Virtual Science Fair, developed community impact projects for JSM 2023 and 2024, and actively contributed to other organizational and peer-review activities. Her service to the Department of Biostatistics includes participating on the hiring and staff onboarding committees, the causal inference working group, and the Ethical Responsibilities Regarding Race in Research group. Outside of biostatistics, Birdrow loves listening to podcasts and music, watching reality TV and documentaries, spending time with her dog, and going for long walks.
New research points way to more reliable brain studies
PhD candidate Kaidi Kang is first author of the study, with advisor Simon Vandekar as corresponding senior author. Co-authors include PhD candidates Jiangmei Xiong and Megan Jones, associate professor Ran Tao, and professor Jonathan Schildcrout.
Potential treatment eyed for abnormal blood cell disorder
Co-authors include senior biostatistician Yajing Li and assistant professor Yaomin Xu.
Vanderbilt Biostatistics at CMStats
Every December, Vanderbilt Biostatistics is represented at the International Joint Conference on Computational and Financial Econometrics (CFE) and Computational and Methodological Statistics (CMStatistics). The 18th edition of the conference will take place December 14–16, 2024, at King's College London and online. Here is this year's cohort, comprising department faculty and alumni:
- Bryan Blette, invited speaker - Exploring the nature of individualized treatment effects using a large crossover trial
- Jonathan Chipman (PhD 2019), invited speaker: Experimenting with finite to infinite populations
- Chiara Di Gravio (PhD 2023), invited speaker: Studying mortality in critically ill patients: An analysis of ordinal longitudinal data under case-control sampling (presentation co-authored by Ran Tao and Jonathan Schildcrout)
- Amber Hackstadt, invited speaker: A Bayesian approach to studying major adverse cardiovascular events: Leveraging information from clinical trials (co-authors include Cara Lwin and Robert Greevy)
- Hakmook Kang, invited speaker: Whole brain connectivity estimation by GPU-enhanced Gaussian process (co-authors include Chris Fonnesbeck)
- Dandan Liu, invited speaker: Predictive partly conditional model for longitudinal outcomes in the presence of informative dropout and death
- Bryan Shepherd, invited speaker: Design and analysis of a multi-wave two-phase study to addresses data errors in a multinational HIV research network
- Andrew Spieker
- organizer/chair, Methodology and practice for data originating from randomized trials
- invited speaker, Causal mediation analysis of engagement for randomized trials involving mobile health interventions
- Simon Vandekar, organizer/chair: Statistical methods for brain imaging data
- Panpan Zhang, organizer/chair: Statistical and computational methods for longitudinal and survival data
Onur Orun promoted to principal biostatistician
We are pleased to announce the promotion of Onur M. Orun to principal biostatistician, effective October 1. Orun earned his bachelor's degree in mathematics from Izmir University of Economics in Turkey, followed by a MS in math from Bilkent University (Ankara, Turkey) and a MS in statistics from Colorado State University, with his master's project focusing on alumni association membership retention at CSU. At Vanderbilt University Medical Center since 2019, Orun has collaborated primarily with Vanderbilt's Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, playing a lead role in creating statistical analysis plans and high-quality, reproducible reports for randomized controlled trials and observational studies, with first-authorship of "Statistical analysis plan for the Surgery for Cancer with Option of Palliative Care Expert (SCOPE) trial: A randomized controlled trial of a specialist palliative care intervention for patients undergoing surgery for cancer" (Trials 2021). Orun has co-authored nine other peer-reviewed publications to date, in high-impact journals such as Lancet: Respiratory Medicine, JAMA Surgery, Chest, and New England Journal of Medicine, and won our department's Linda Stewart Applied Analysis Report Award twice, in 2019 for "Vitamin D to Improve Outcomes by Leveraging Early Treatment: Long-term Brain Outcomes in Vitamin D Deficient Patients (VIOLET-BUD)" and in 2023 for "BRAIN-ICU Long-term Outcomes Latent Trajectory Analysis Report." Away from his computer, his interests include foodie adventures and hiking. Click his name to view his staff profile.