Congratulations to professor of biostatistics and health policy William D. Dupont, PhD, FASA, on the publication of Coding Variants of the Genitourinary Development Gene WNT9B Carry High Risk for Prostate Cancer, published January 28 in JCO Precision Oncology in collaboration with Angela Jones (VANTAGE), Jeffrey R. Smith (Department of Medicine), and the VA Million Veteran Program. Dr. Dupont and Dr. Smith are also affiliated with the Medical Research Service of the Tennessee Valley Healthcare System, and the study was supported by grants from the Veterans Health Administration, the V Foundation for Cancer Research, and the National Institutes of Health, with data drawn from the NIH's All of Us program, the Nashville Familial Prostate Cancer Study (NFPCS), the International Consortium for Prostate Cancer Genetics (ICPCG), UK Biobank, and FinnGen.
The goal of the study was to detect and confirm potential links between specific genes and hereditary prostate cancer. Dr. Dupont and his colleagues used genome-wide single-allele and identity-by-descent analytic approaches to identify pathogenic variants (i.e., mutations) that prostate cancer patients might have in common, and then attempted to replicate their observations with data from the biobanks listed above, confirming the association of two genes — HOXB13 and WNT9B — with high risk of prostate cancer. The paper is the first to discuss WNT9B as a factor in the transmission of prostate cancer. Both genes are vital to prostate development, which suggests that other genes with that characteristic may likewise elevate an individual's risk of developing genitourinary cancer. This new knowledge can help biomedical researchers develop ways to prevent and treat this type of cancer.
